Stepwise SMILES Variant Generator

Base Molecule SMILES

Random Attempts

Top Results

Seed

Generation Mode

Random All possible sites

Stepwise Change Types

Add one atom/group Remove terminal atom/group Bond valence change Open one ring Close one ring

Results To Show

Top N All Unique Valid Variants

Heavy Atom / Fragment Choices

Custom User Fragment

Fragment SMILES or shorthand

Display Label

Attachment Bond

Show Possible Inputs table

Each result is one stepwise change: one atom/group add/remove, one bond-order change, or one ring open/close.